Areas of expertise
Ecotoxicogenomics , Animal physiology , Chemical and environmental toxicology , Endocrine disruption , Endocrinology , Molecular biology
- Full Professor
- Chairholder of the Canada Research Chair in Ecotoxicogenomics and Endocrin Disruption
- Scientific head of the Ecotoxicogenomics and Endocrine Disruption Laboratory
Phone
418-654-2547
Eau Terre Environnement Research Centre
490 rue de la Couronne Street
Québec, Quebec G1K 9A9
CANADA
Research interests
Professor Langlois is particularly interested in the harmful effects on vertebrates of chemicals present in aquatic environments. These substances can potentially affect all stages of cellular regulation in aquatic vertebrates, from hormone synthesis to target cell responses, and consequently they can alter the metabolism, development, and reproduction of vertebrates.
The main theme of her research program is the identification of physiological responses and regulatory mechanisms in vertebrates exposed to environmental contaminants. For more than 10 years, she has been working with academic and government partners to determine the harmful effects of these contaminants on vertebrates. Her main research axes are:
Axis 1: Metabolism of polycyclic aromatic hydrocarbons in aquatic species
Axis 2: Emerging pollutants and their impact on the development of aquatic species
Axis 3: Endocrine disruptors in aquatic species
Publications
Colson, Tash-Lynn L.; de Solla, Shane R. & Langlois, Valérie S. (2021). Bioaccumulation and physiological responses of the turtle Chelydra serpentina exposed to polychlorinated biphenyls during early life stages. Chemosphere, 263: Art. 128146.
DOI: 10.1016/j.chemosphere.2020.128146
Empey, Madelaine A.; Lefebvre-Raine, Molly; Gutierrez-Villagomez, Juan Manuel; Langlois, Valérie S. & Trudeau, Vance L. (2021). A review of the effects of the biopesticides Bacillus thuringiensis serotypes israelensis (Bti) and kurstaki (Btk) in amphibians. Arch. Environ. Con. Toxicol., 80: 789-800.
Langlois, Valérie S. (2021). Amphibian toxicology: A rich but underappreciated model for ecotoxicology research. Arch. Environ. Con. Toxicol., 80: 661-662.
Lara-Jacobo, Linda Ramona; Gauthier, Charles; Xin, Qin; Dupont, Félix; Couture, Patrice; Triffault-Bouchet, Gaëlle; Dettman, Heather & Langlois, Valérie S. (2021). Fate and fathead minnow embryotoxicity of weathering crude oil in a pilot-scale spill tank. Environ. Toxicol. Chem., 40 (1): 127-138.
DOI: 10.1002/etc.4891
Lebordais, Marc; Gutierrez-Villagomez, Juan Manuel; Gigault, Julien; Baudrimont, Magalie & Langlois, Valérie S. (2021). Molecular impacts of dietary exposure to nanoplastics combined with arsenic in Canadian oysters (Crassostrea virginica) and bioaccumulation comparison with Caribbean oysters (Isognomon alatus). Chemosphere, 27: Art. 130331.
Lebordais, Marc; Venel, Zélie; Gigault, Julien; Langlois, Valérie S. & Baudrimont, Magalie (2021). Molecular impacts of dietary exposure to nanoplastics combined or not with arsenic in the Caribbean mangrove oysters (Isognomon alatus). Nanomaterials, 11 (5): Art. 1151.
Lefebvre-Raine, Molly; Paquet, N.; Triffault-Bouchet, Gaëlle & Langlois, Valérie S. (2021). Embryotoxicity of five cytostatics in fathead minnow (Pimephales promelas) larvae. Bull. Env. Contam. Toxicol., 106: 747-752.
DOI: 10.1007/s00128-021-03146-2
Thomson, Paisley; Pineda, Marco; Yargeau, Viviane & Langlois, Valérie S. (2021). Chronic exposure to two gestagens differentially alters morphology and gene expression in Silurana tropicalis. Arch. Environ. Con. Toxicol., 80: 745-759.
Adams, Julie E.; Madison, Barry N.; Charbonneau, Kelli; Sereneo, Marie; Baillon, Lucie; Langlois, Valérie S.; Brown, Stephen R. & Hodson, Peter V. (2020). Effects on trout alevins of chronic exposures to chemically-dispersed Access Western Blend and Cold Lake Blend dilbits. Environ. Toxicol. Chem., 39 (8): 1620-1633.
DOI: 10.1002/etc.4747
Castaneda Cortes, Diana C.; Zhang, Jing; Boan, Augustin F.; Langlois, Valérie S. & Fernandino, Juan I. (2020). High temperature stress response is not sexually dimorphic at the whole-body level and is dependent on androgens to induce sex reversal. Gen. Comp. Endocrinol., 299: Art. 113605.
DOI: 10.1016/j.ygcen.2020.113605
Colson, Tash-Lynn L.; de Solla, Shane R.; Balakrishnan, Vimal K.; Toito, John & Langlois, Valérie S. (2020). N-phenyl-1-naphthylamine (PNA) accumulates in snapping turtle (Chelydra serpentina) liver activating the detoxification pathway. Bull. Env. Contam. Toxicol., 105: 813-818.
DOI: 10.1007/s00128-020-03043-0
Dominique, Mélanie; Letcher, Robert J.; Rutter, Allison & Langlois, Valérie S. (2020). Comparative review of the distribution and burden of contaminants in the body of polar bears. Environ. Sci. Pollut. Res., 27: 32456–32466.
DOI: 10.1007/s11356-020-09193-2
Hayhurst, Lauren D.; Martin, Jonathan D.; Wallace, Sarah J.; Langlois, Valérie S.; Xenopoulos, Marguerite A.; Metcalfe, Chris D. & Rennie, Michael D. (2020). Multi-level responses of yellow perch (Perca flavescens) to a whole-lake nanosilver addition study. Arch. Environ. Con. Toxicol., 79 (3): 283-297.
DOI: 10.1007/s00244-020-00764-5
Hodson, Peter V.; Wallace, Sarah J.; de Solla, Shane R.; Head, Jessica A.; Hepditch, Scott; Parrott, Joanne L.; Thomas, Philippe J.; Berthiaume, Alicia & Langlois, Valérie S. (2020). Polycyclic aromatic compounds (PACs) in the Canadian environment: The challenges of ecological risk assessments. Environ. Pollut., 266 part 2: Art. 115165.
DOI: 10.1016/j.envpol.2020.115165
Langlois, Valérie S.; Allison, Michael J.; Bergman, Lauren C.; To, Tuan Anh & Helbing, Caren C. (2020). The need for robust qPCR-based eDNA detection assays in environmental monitoring and species inventories. Environ. DNA, ONLINE.
DOI: 10.1002/edn3.164
Madison, Barry N.; Wallace, Sarah J.; Zhang, Jing; Hodson, Peter V. & Langlois, Valérie S. (2020). Transcriptional responses in newly-hatched Japanese medaka (Oryzias latipes) associated with developmental malformations following diluted bitumen exposure. Comp. Biochem. Physiol. (D) Genom. Proteom., 35: Art. 100685.
DOI: 10.1016/j.cbd.2020.100685
Robitaille, Julie & Langlois, Valérie S. (2020). Consequences of steroid-5″-reductase deficiency and inhibition in vertebrates. Gen. Comp. Endocrinol., 290: Art. 13400.
DOI: 10.1016/j.ygcen.2020.113400
Timlick, Lauren; Peters, Lisa E.; Wallace, Sarah J.; Dettman, Heather; Brown, Stephen R.; Mason, Johanna; Langlois, Valérie S. & Palace, Vince P. (2020). Effects of environmentally relevant residual levels of diluted bitumen on wild fathead minnows (Pimephales promelas). Bull. Env. Contam. Toxicol., 105: 699-704.
DOI: 10.1007/s00128-020-03008-3
Trudeau, Vance L.; Thompson, Paisley E; Zhang, Wo Su; Reynaud, Stephane; Navarro-Martin, Laia & Langlois, Valérie S. (2020). Agrochemicals disrupt multiple endocrine axes in amphibians. Mol. Cell. Endocrino., 513: Art. 110861.
DOI: 10.1016/j.mce.2020.110861
Wallace, Sarah J.; Leclerc, A. J. A.; Prosser, R. S.; de Solla, Shane R.; Balakrishnan, V. K. & Langlois, Valérie S. (2020). Sub-lethal effects of calcium dinonylnaphthalenesulfonate on Western clawed frog embryos. Comp. Biochem. Physiol. (D) Genom. Proteom., 34: Art. 100658.
DOI: 10.1016/j.cbd.2020.100658
Wallace, Sarah J.; de Solla, Shane R.; Head, Jessica A.; Hodson, Peter V.; Parrott, Joanne L.; Thomas, Philippe J.; Berthiaume, Alicia & Langlois, Valérie S. (2020). Polycyclic aromatic compounds (PACs) in the Canadian environment: Exposure and effects on wildlife. Environ. Pollut., 265 part B: Art. 114863.
DOI: 10.1016/j.envpol.2020.114863
Beirao, Jose; Baillon, Lucie; Litt, Margaret A.; Langlois, Valérie S. & Purchase, Craig F. (2019). Impact of crude oil and the dispersant CorexitTM EC9500A on capelin (Mallotus villosus) embryo development. Mar. Environ. Res., 147: 90-100.
DOI: 10.1016/j.marenvres.2019.04.004
Castaneda Cortes, Diana C.; Arias Padilla, Luisa F.; Langlois, Valérie S.; Somoza, Gustavo M. & Fernandino, Juan I. (2019). The central nervous system acts as a transducer of stress-induced masculinization through corticotropin-releasing hormone B. Development, 146 (8): Art. dev172866.
DOI: 10.1242/dev.172866
Gutierrez-Villagomez, Juan Manuel; Martyniuk, Christopher J.; Xing, Lei; Langlois, Valérie S.; Pauli, Bruce D.; Blais, Jules M. & Trudeau, Vance L. (2019). Transcriptome analysis reveals that naphthenic acids perturb gene networks related to metabolic processes, membrane integrity, and gut function in Silurana (Xenopus) tropicalis embryos. Front. Mar. Sci., 6: Art. 533.
DOI: 10.3389/fmars.2019.00533
Lara-Jacobo, Linda Ramona; Williard, Brianna; Wallace, Sarah J. & Langlois, Valérie S. (2019). Cytochrome P450 1A transcript is a suitable biomarker of both exposure and response to diluted bitumen in developing frog embryos. Environ. Pollut., 246: 501-508.
DOI: 10.1016/j.envpol.2018.12.039
McDonnell, Denby; Barry, Madison N.; Baillon, Lucie; Wallace, Sarah J.; Brown, Stephen R.; Hodson, Peter V. & Langlois, Valérie S. (2019). Comparative toxicity of two diluted bitumens to developing yellow perch (Perca flavescens). Sci. Total Environ., 655: 977-985.
DOI: 10.1016/j.scitotenv.2018.11.199
Zhang, Jing; Knight, Rosalinda; Wang, Yushan; Sawyer, Thomas W.; Martyniuk, Christopher J. & Langlois, Valérie S. (2019). Hair follicle miRNAs: a novel biomarker for primary blast induced-mild traumatic brain injury. Biomarkers, 24 (2): 166-179.
DOI: 10.1080/1354750X.2018.1531929
Alsaadi, Ftoon; Hodson, Peter V. & Langlois, Valérie S. (2018). An embryonic field of study: The aquatic fate and toxicity of diluted bitumen. Bull. Env. Contam. Toxicol., 100 (1): 8-13.
DOI: 10.1007/s00128-017-2239-7
Alsaadi, Ftoon; Madison, Barry N.; Brown, R. S.; Hodson, P. V. & Langlois, Valérie S. (2018). Morphological and molecular effects of two diluted bitumens on developing fathead minnow (Pimephales promelas). Aquat. Toxicol., 204: 107-116.
DOI: 10.1016/j.aquatox.2018.09.003
Bissegger, Sonja; Castro, Marco A. Pineda; Yargeau, Viviane & Langlois, Valérie S. (2018). Phthalates modulate steroid 5-reductase transcripts in the Western clawed frog embryo. Comp. Biochem. Physiol. (C), 213: 39-46.
DOI: 10.1016/j.cbpc.2018.07.005
Campbell, Diana E. K. & Langlois, Valérie S. (2018). Expression of sf1 and dax-1 are regulated by thyroid hormones and androgens during Silurana tropicalis early development. Gen. Comp. Endocr., 259: 34-44.
DOI: 10.1016/j.ygcen.2017.10.017
Campbell, Diana E. K. & Langlois, Valérie S. (2018). Thyroid hormones and androgens differentially regulate gene expression in testes and ovaries of sexually mature Silurana tropicalis. Gen. Comp. Endocr., 267: 172-182.
DOI: 10.1016/j.ygcen.2018.07.001
Campbell, Diana E. K.; Montgomerie, Robert D. & Langlois, Valérie S. (2018). Lifecycle exposure to perchlorate differentially alters morphology, biochemistry, and transcription as well as sperm motility in Silurana tropicalis frogs. Environ. Pollut., 237: 196-204.
DOI: 10.1016/j.envpol.2018.02.038
Thompson, Paisley & Langlois, Valérie S. (2018). Developmental profiles of progesterone receptor transcripts and molecular responses to gestagen exposure during Silurana tropicalis early development. Gen. Comp. Endocr., 265: 4-14.
DOI: 10.1016/j.ygcen.2018.05.017
Wallace, S. J.; de Solla, S. R.; Thomas, P. J.; Harner, T.; Eng, A. & Langlois, Valérie S. (2018). Airborne polycyclic aromatic compounds contribute to the induction of the tumour-suppressing P53 pathway in wild double-crested cormorants. Ecotox. Environ. Safe., 150: 176-189.
DOI: 10.1016/j.ecoenv.2017.12.028