{"id":20030,"date":"2020-08-31T08:01:17","date_gmt":"2020-08-31T08:01:17","guid":{"rendered":"https:\/\/dev.inrs.ca\/?post_type=project&#038;p=20030"},"modified":"2022-06-02T10:57:44","modified_gmt":"2022-06-02T14:57:44","slug":"biology-of-the-interactions-between-leishmania-parasites-and-the-immune-system-bon","status":"publish","type":"project","link":"https:\/\/dev.inrs.ca\/en\/les-etudes\/projets-de-maitrise-et-de-doctorat\/repertoire-des-projets-etudes\/biology-of-the-interactions-between-leishmania-parasites-and-the-immune-system\/","title":{"rendered":"Biology of the interactions between Leishmania parasites and the immune system"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Project description<\/h2>\n\n\n\n<p>The protozoan parasite <em>Leishmania<\/em> is the cause of human diseases known as leishmaniasis. <em>Leishmania<\/em> pathology can take different forms, from simple skin lesions (cutaneous leishmaniosis) to potentially fatal visceral infection (visceral leishmaniosis). The intracellular parasite infects macrophages, dendritic cells and neutrophils, which all play a crucial role in T lymphocyte activation and inflammatory responses. Our laboratory uses molecular and cell biology approaches to elucidate the mechanisms by which <em>Leishmania <\/em>alters the host cell membrane fusion machinery, and to study the consequences of these alterations on the functionality of infected cells and on the immune response.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Research areas<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>host-pathogen interactions<\/li><li>cell biology<\/li><li>immune response<\/li><li><em>Leishmania<\/em><\/li><li>macrophages<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Starting date<\/h2>\n\n\n\n<p>Fall 2020<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Research advisor<\/h2>\n\n\n\n<p><a href=\"https:\/\/dev.inrs.ca\/en\/professors\/albert-descoteaux\/\">Albert Descoteaux<\/a>, professor<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Financial support<\/h2>\n\n\n\n<p>This project is funded by the <a href=\"https:\/\/cihr-irsc.gc.ca\/e\/193.html\">Canadian Institutes of Health Research<\/a> (CIHR). Furthermore, INRS offers Every student-researcher benefits from a grant during their higher education studies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Program of study<\/h2>\n\n\n\n<p><a href=\"https:\/\/dev.inrs.ca\/les-etudes\/programmes-d-etudes\/repertoire-des-programmes-d-etudes\/maitrise-en-virologie-et-immunologie-3695\/\">Master&#8217;s in virology and immunology<\/a> (French description) or <a href=\"https:\/\/dev.inrs.ca\/les-etudes\/programmes-d-etudes\/repertoire-des-programmes-d-etudes\/doctorat-en-virologie-et-immunologie-1749\/\">PhD in virology and immunology<\/a> (French description)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Profile<\/h2>\n\n\n\n<p>The candidate should have a bachelor\u2019s degree (with a minimum average of 3\/3.4) or a MSc degree (or equivalent for the Ph.D programme) depending on the program of interest and experience in microbiology, immunology or cell biology.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br>Location<\/h2>\n\n\n\n<p><a href=\"https:\/\/dev.inrs.ca\/en\/research-centres\/armand-frappier-sante-biotechnologie-research-centre\/\">Armand-Frappier Sant\u00e9 Biotechnologie Research Centre<br><\/a>531, boulevard des Prairies<br>Laval, Qu\u00e9bec G7V 1B7<br>Canada<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><br><strong>How to apply<\/strong><\/h2>\n\n\n\n<p>Interested candidates can submit their application to Albert Descoteaux by using the online form. The application must include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>CV<\/li><li>their curriculum, an official transcript<\/li><li>a motivation letter<\/li><li>the name and contact information of two references.<\/li><\/ul>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"frm_forms  with_frm_style frm_style_formidable-style\" id=\"frm_form_78_container\" >\n<form enctype=\"multipart\/form-data\" method=\"post\" class=\"frm-show-form  frm_pro_form \" id=\"form_descoteaux-albert-20-1-en\" >\n<div class=\"frm_form_fields \">\n<fieldset>\n<legend class=\"frm_screen_reader\">Project Albert Descoteaux - Biology of the interactions between Leishmania parasites and the immune system<\/legend>\r\n\r\n<div class=\"frm_description\"><p>Project title : Biology of the interactions between Leishmania parasites and the immune system<\/p>\n<\/div><div class=\"frm_fields_container\">\n<input type=\"hidden\" name=\"frm_action\" value=\"create\" \/>\n<input type=\"hidden\" name=\"form_id\" value=\"78\" \/>\n<input type=\"hidden\" name=\"frm_hide_fields_78\" id=\"frm_hide_fields_78\" value=\"\" \/>\n<input type=\"hidden\" name=\"form_key\" value=\"descoteaux-albert-20-1-en\" \/>\n<input type=\"hidden\" name=\"item_meta[0]\" value=\"\" \/>\n<input type=\"hidden\" id=\"frm_submit_entry_78\" name=\"frm_submit_entry_78\" value=\"e50553b578\" \/><input type=\"hidden\" name=\"_wp_http_referer\" value=\"\/en\/wp-json\/wp\/v2\/project\/20030\" \/><div id=\"frm_field_746_container\" class=\"frm_form_field form-field  frm_required_field frm_top_container frm_third\">\r\n    <label for=\"field_i3hhf2d0e09f8f6b1124bc5ca4bb5165a9f7723783d14394d29b1f45d933b4aaa\" id=\"field_i3hhf2d0e09f8f6b1124bc5ca4bb5165a9f7723783d14394d29b1f45d933b4aaa_label\" class=\"frm_primary_label\">First Name\r\n        <span class=\"frm_required\">*<\/span>\r\n    <\/label>\r\n    <input  type=\"text\" 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Maximum file size: 5MB\">Choisir un fichier<\/button><\/span>\n\t\t<div class=\"frm_small_text\">\n\t\t\t<p>Maximum file size: 5MB<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\t\r\n    \r\n    \r\n<\/div>\n<div id=\"frm_field_753_container\" class=\"frm_form_field form-field  frm_required_field frm_top_container frm_fourth\">\r\n    <div  id=\"field_8mr26bba205d67b2b9992deb58eae98dc5676e254620e593dbad65b76282821ab_label\" class=\"frm_primary_label\">Motivation letter\r\n        <span class=\"frm_required\">*<\/span>\r\n    <\/div>\r\n    <input type=\"hidden\"  data-reqmsg=\"Veuillez ajouter le document\" data-invmsg=\"Le format de votre fichier est invalide\" class=\"auto_width\" aria-invalid=\"false\"   name=\"item_meta[753]\"  data-reqmsg=\"Veuillez ajouter le document\"  value=\"\" data-frmfile=\"753\" \/>\n\n<div class=\"frm_dropzone frm_single_upload frm_clearfix\" id=\"file753_dropzone\" role=\"group\" >\n\t<div class=\"fallback\">\n\t\t<input type=\"file\" name=\"file753\" id=\"field_8mr26bba205d67b2b9992deb58eae98dc5676e254620e593dbad65b76282821ab\"\n\t\t\t data-reqmsg=\"Veuillez ajouter le document\" data-invmsg=\"Le format de votre fichier est invalide\" class=\"auto_width\" aria-invalid=\"false\"  \t\t\t\/>\n\t\t\t\t<div class=\"frm_clearfix \"><\/div>\n\t<\/div>\n\t<div class=\"dz-message needsclick\">\n\t\t\t\t<svg  viewBox=\"0 0 18 18\" class=\"frmsvg frm-svg-icon\">\n\t<path viewBox=\"0 0 18 18\" fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M8.2 4v8a.8.8 0 001.5 0V4l2.1 2.2A.7.7 0 1013 5L9.5 1.7a.7.7 0 00-1.1 0L5.1 5.2a.8.8 0 001 1l2.1-2zm7.6 4.3c.4 0 .7.3.7.7v6.8c0 .4-.3.7-.8.7H2.3a.8.8 0 01-.8-.8V9A.8.8 0 013 9v6h12V9c0-.4.3-.8.8-.8z\"><\/path>\n<\/svg>\t\t<span class=\"frm_upload_text\"><button type=\"button\" aria-label=\"Motivation letter. 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Maximum file size: 5MB\">Choisir un fichier<\/button><\/span>\n\t\t<div class=\"frm_small_text\">\n\t\t\t<p>Maximum file size: 5MB<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\t\r\n    \r\n    \r\n<\/div>\n<div id=\"frm_field_754_container\" class=\"frm_form_field form-field  frm_top_container frm10\">\r\n    <label for=\"field_s8u9r9170cc1fc50a88a43bf50d537c3d0705384603572c1f89bc680c9af56b03\" id=\"field_s8u9r9170cc1fc50a88a43bf50d537c3d0705384603572c1f89bc680c9af56b03_label\" class=\"frm_primary_label\">Questions, comments\r\n        <span class=\"frm_required\"><\/span>\r\n    <\/label>\r\n    <textarea name=\"item_meta[754]\" id=\"field_s8u9r9170cc1fc50a88a43bf50d537c3d0705384603572c1f89bc680c9af56b03\" rows=\"5\"  data-invmsg=\"Questions, comments is invalid\" aria-invalid=\"false\"  ><\/textarea>\r\n    \r\n    \r\n<\/div>\n<div id=\"frm_field_755_container\" class=\"frm_form_field form-field  frm_none_container\">\r\n    <label for=\"g-recaptcha-response\" id=\"field_575ov6af20e177c1fb3e74748ea68987c8dbf21e9f44962007811dbfda86379d4_label\" class=\"frm_primary_label\">reCAPTCHA\r\n        <span class=\"frm_required\"><\/span>\r\n    <\/label>\r\n    <div  id=\"field_575ov6af20e177c1fb3e74748ea68987c8dbf21e9f44962007811dbfda86379d4\" class=\"frm-g-recaptcha\" data-sitekey=\"6LeGVLoZAAAAADqtVtYpysFxvIU-IKPEMiHnXdEp\" data-size=\"invisible\" data-theme=\"light\"><\/div>\r\n    \r\n    \r\n<\/div>\n\t<input type=\"hidden\" name=\"item_key\" value=\"\" \/>\n\t<input name=\"frm_state\" type=\"hidden\" value=\"1mzpao6SG\/KMKMHd6EunZU3N0b1SyBp9dLskPs+C8jo6nJs6ug\/mAEvPK3o2oWKl\" \/><div class=\"frm_submit\">\r\n\r\n<button class=\"frm_button_submit frm_final_submit\" type=\"submit\"   formnovalidate=\"formnovalidate\">SEND MY APPLICATION<\/button>\r\n\r\n<\/div><\/div>\n<\/fieldset>\n<\/div>\n\n<\/form>\n<\/div>\n\n\n\n\n<h2 class=\"wp-block-heading\"><br>Questions<\/h2>\n\n\n\n<p><strong>Albert Descoteaux, PhD<\/strong><br>Email : <a href=\"mailto:albert.descoteaux@iaf.dev.inrs.ca\">albert.descoteaux@iaf.dev.inrs.ca<\/a><br>Phone : 450-687-5010 extension 4465<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project description The protozoan parasite Leishmania is the cause of human diseases known as leishmaniasis. Leishmania pathology can take different forms, from simple skin lesions (cutaneous leishmaniosis) to potentially fatal visceral infection (visceral leishmaniosis). The intracellular parasite infects macrophages, dendritic cells and neutrophils, which all play a crucial role in T lymphocyte activation and inflammatory [&hellip;]<\/p>\n","protected":false},"featured_media":18331,"parent":19967,"template":"","sectors":[679],"expertise":[1090,818,1242,1243,804],"project_type":[747],"professor_program":[1199],"class_list":["post-20030","project","type-project","status-publish","has-post-thumbnail","hentry","sectors-sante-en","expertise-antiviral-and-antitumor-immune-responses","expertise-cellular-biology","expertise-leishmania","expertise-macrophages","expertise-host-pathogen-interactions","project_type-project-en","professor_program-virology-and-immunology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.6 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Biology of the interactions between Leishmania parasites and the immune system | INRS<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biology of the interactions between Leishmania parasites and the immune system | INRS\" \/>\n<meta property=\"og:description\" content=\"Project description The protozoan parasite Leishmania is the cause of human diseases known as leishmaniasis. Leishmania pathology can take different forms, from simple skin lesions (cutaneous leishmaniosis) to potentially fatal visceral infection (visceral leishmaniosis). The intracellular parasite infects macrophages, dendritic cells and neutrophils, which all play a crucial role in T lymphocyte activation and inflammatory [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.inrs.ca\/en\/les-etudes\/projets-de-maitrise-et-de-doctorat\/repertoire-des-projets-etudes\/biology-of-the-interactions-between-leishmania-parasites-and-the-immune-system\/\" \/>\n<meta property=\"og:site_name\" content=\"INRS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/inrsciences\/\" \/>\n<meta property=\"article:modified_time\" content=\"2022-06-02T14:57:44+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@inrsciences\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" 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