{"id":13460,"date":"2020-08-04T19:56:19","date_gmt":"2020-08-04T19:56:19","guid":{"rendered":"https:\/\/dev.inrs.ca\/professeurs\/professors\/stephane-lefrancois\/"},"modified":"2021-08-31T08:52:40","modified_gmt":"2021-08-31T12:52:40","slug":"stephane-lefrancois","status":"publish","type":"professor","link":"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/","title":{"rendered":"St\u00e9phane Lefran\u00e7ois"},"author":1,"featured_media":23175,"parent":13241,"template":"","sectors":[679],"expertise":[849,818,995],"taxo_thematic":[1186],"professor_program":[825,1196,1199],"professor_education_offer":[],"expertise_groups":[1652,1711,1713,1714,1662],"class_list":["post-13460","professor","type-professor","status-publish","has-post-thumbnail","hentry","sectors-sante-en","expertise-biophysic","expertise-cellular-biology","expertise-neurodegenerative-diseases","taxo_thematic-infection-and-immunity","professor_program-biology","professor_program-experimental-health-sciences","professor_program-virology-and-immunology","expertise_groups-biogeochemistry","expertise_groups-chronic-or-inflammatory-diseases","expertise_groups-neurodegenerative-diseases","expertise_groups-rare-diseases","expertise_groups-stem-cells"],"acf":[],"yoast_head":"\nSt\u00e9phane Lefran\u00e7ois | INRS<\/title>\n<meta name=\"description\" content=\"Research project for a Master's student in experimental health sciences or Doctorate in Biology :Study of intracellular trafficking in neurodegenerative diseases\u00a0(PDF)The goal of my research program is to elucidate the mechanisms cells use to regulate intracellular sorting and trafficking with an emphasis on sorting to and from the lysosomal compartment and the basolateral compartment of polarised cells. The efficient sorting and trafficking to the lysosome is a crucial cellular function that has important implications in human health. Although individually rare, the combined occurrence of the more than 50 Lysosomal Storage Disorders (LSDs) have been reported at 1:5000 live births. Interestingly, proteins required in lysosomal sorting and trafficking have been implicated in various other diseases, notably muscular dystrophy, diabetes and Alzheimer\u2019s disease. Using a multifaceted approach that includes cell and molecular biology, biochemistry, high content image acquisition\/image analysis, live cell imaging and Bioluminescence Resonance Energy Transfer (BRET), we will identify and characterize key regulators that control intracellular sorting and trafficking that will increase our knowledge on the fundamental aspects of this system and could serve as therapeutic targets for these various diseases.\u00a0\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"St\u00e9phane Lefran\u00e7ois | INRS\" \/>\n<meta property=\"og:description\" content=\"Research project for a Master's student in experimental health sciences or Doctorate in Biology :Study of intracellular trafficking in neurodegenerative diseases\u00a0(PDF)The goal of my research program is to elucidate the mechanisms cells use to regulate intracellular sorting and trafficking with an emphasis on sorting to and from the lysosomal compartment and the basolateral compartment of polarised cells. The efficient sorting and trafficking to the lysosome is a crucial cellular function that has important implications in human health. Although individually rare, the combined occurrence of the more than 50 Lysosomal Storage Disorders (LSDs) have been reported at 1:5000 live births. Interestingly, proteins required in lysosomal sorting and trafficking have been implicated in various other diseases, notably muscular dystrophy, diabetes and Alzheimer\u2019s disease. Using a multifaceted approach that includes cell and molecular biology, biochemistry, high content image acquisition\/image analysis, live cell imaging and Bioluminescence Resonance Energy Transfer (BRET), we will identify and characterize key regulators that control intracellular sorting and trafficking that will increase our knowledge on the fundamental aspects of this system and could serve as therapeutic targets for these various diseases.\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/\" \/>\n<meta property=\"og:site_name\" content=\"INRS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/inrsciences\/\" \/>\n<meta property=\"article:modified_time\" content=\"2021-08-31T12:52:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2020\/04\/Lefrancois_Stephane_0172.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"707\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@inrsciences\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/\",\"url\":\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/\",\"name\":\"St\u00e9phane Lefran\u00e7ois | INRS\",\"isPartOf\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2020\/04\/Lefrancois_Stephane_0172.jpg\",\"datePublished\":\"2020-08-04T19:56:19+00:00\",\"dateModified\":\"2021-08-31T12:52:40+00:00\",\"description\":\"Research project for a Master's student in experimental health sciences or Doctorate in Biology :Study of intracellular trafficking in neurodegenerative diseases\u00a0(PDF)The goal of my research program is to elucidate the mechanisms cells use to regulate intracellular sorting and trafficking with an emphasis on sorting to and from the lysosomal compartment and the basolateral compartment of polarised cells. 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Using a multifaceted approach that includes cell and molecular biology, biochemistry, high content image acquisition\/image analysis, live cell imaging and Bioluminescence Resonance Energy Transfer (BRET), we will identify and characterize key regulators that control intracellular sorting and trafficking that will increase our knowledge on the fundamental aspects of this system and could serve as therapeutic targets for these various diseases.\u00a0\",\"breadcrumb\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/#breadcrumb\"},\"inLanguage\":\"en-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-CA\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/#primaryimage\",\"url\":\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2020\/04\/Lefrancois_Stephane_0172.jpg\",\"contentUrl\":\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2020\/04\/Lefrancois_Stephane_0172.jpg\",\"width\":900,\"height\":707},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/research\/professors\/stephane-lefrancois\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Research\",\"item\":\"https:\/\/dev.inrs.ca\/la-recherche\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Professors\",\"item\":\"https:\/\/dev.inrs.ca\/la-recherche\/professeurs\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"St\u00e9phane Lefran\u00e7ois\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/#website\",\"url\":\"https:\/\/dev.inrs.ca\/en\/\",\"name\":\"INRS\",\"description\":\"Institut national de la recherche scientifique\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dev.inrs.ca\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-CA\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"St\u00e9phane Lefran\u00e7ois | INRS","description":"Research project for a Master's student in experimental health sciences or Doctorate in Biology :Study of intracellular trafficking in neurodegenerative diseases\u00a0(PDF)The goal of my research program is to elucidate the mechanisms cells use to regulate intracellular sorting and trafficking with an emphasis on sorting to and from the lysosomal compartment and the basolateral compartment of polarised cells. 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