{"id":62704,"date":"2021-06-10T08:05:05","date_gmt":"2021-06-10T12:05:05","guid":{"rendered":"https:\/\/dev.inrs.ca\/?p=62704"},"modified":"2021-06-10T08:05:12","modified_gmt":"2021-06-10T12:05:12","slug":"prostate-cancer-linked-to-obesity","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/prostate-cancer-linked-to-obesity\/","title":{"rendered":"Prostate cancer linked to obesity"},"content":{"rendered":"\n

An INRS team is investigating the relationship between body mass and the risk of developing cancer.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n\n
\"Man
Abdominal obesity appears to be associated with a greater risk of developing aggressive prostate cancer.<\/figcaption><\/figure><\/div>\n\n\n\n
<\/div>\n\n\n\n

Prostate cancer is the most common form of cancer among Canadian men and the third leading cause of cancer death. Abdominal obesity appears to be associated with a greater risk of developing aggressive prostate cancer. This link was demonstrated in a study<\/a> led by Professor Marie-\u00c9lise Parent<\/a> of Institut national de la recherche scientifique (INRS) and published in the journal Cancer Causes & Control<\/a>.<\/p>\n\n\n\n

Over the years, several studies have shown that obesity is a major risk factor for prostate cancer. To further explore the link between disease incidence and body mass, the research team studied data from a survey conducted in Montr\u00e9al between 2005 and 2012. Researchers observed that abdominal obesity was associated with an increased risk of aggressive cancer.<\/p>\n\n\n\n

\u201cPinpointing the risk factors for aggressive cancer is a big step forward in health research because it\u2019s the hardest to treat. This data creates an opportunity to work preventively, by monitoring men with this risk factor more closely.\u201d<\/p>Marie-\u00c9lise Parent, specialist in cancer epidemiology<\/cite><\/blockquote>\n\n\n\n


Abdominal and general obesity<\/strong><\/h2>\n\n\n\n

The actual distribution of body fat appears to be a significant factor in the development of the disease: the impact on a person\u2019s health can vary depending on whether the fat is concentrated around the abdomen or distributed throughout the body. According to \u00c9ric Valli\u00e8res, a Universit\u00e9 de Montr\u00e9al student conducting his doctoral research at INRS and the study\u2019s main author, \u201cAbdominal obesity causes hormonal and metabolic variations that can promote the growth of hormone-dependent cancer cells. Abdominal obesity is believed to be associated with a decrease in testosterone, as well as a state of chronic inflammation linked to the development of aggressive tumours.\u201d<\/p>\n\n\n\n

General obesity did not show the same correlation as abdominal fat. This may result from a detection bias and possible biological effects. \u201cIn obese people, the protein used to detect prostate cancer at an early stage, prostate-specific antigen (PSA), is diluted in the blood,\u201d Mr. Valli\u00e8res says. \u201cThis hemodilution makes cancer more difficult to detect.\u201d<\/p>\n\n\n\n

The research team believes that studies on the timing of obesity exposure over a lifetime should be prioritized, and that a more in-depth analysis of body fat distribution could provide greater insight into the risks of developing prostate cancer.<\/p>\n\n\n\n


About the study<\/strong><\/h3>\n\n\n\n

The article \u201cGeneral and abdominal obesity trajectories across adulthood, and risk of prostate cancer: results from the PROtEuS study, Montreal, Canada<\/a>,\u201d by \u00c9ric Valli\u00e8res, Miceline M\u00e9sidor, Marie-H\u00e9l\u00e8ne Roy-Gagnon, Hugues Richard and Marie-\u00c9lise Parent, was published in Cancer Causes & Control in April. The study received funding from the Canadian Cancer Society<\/a>, the Cancer Research Society<\/a>, Fonds de recherche du Qu\u00e9bec\u2013Sant\u00e9<\/a> (FRQS), Minist\u00e8re de l\u2019\u00c9conomie et de l\u2019Innovation<\/a> and the Canadian Institutes of Health Research<\/a> (CIHR).<\/p>\n\n\n\n


About Marie-\u00c9lise Parent<\/strong><\/h3>\n\n\n\n

Marie-\u00c9lise Parent was recently appointed to the Scientific Council of the International Agency for Research on Cancer<\/a>, a component of the World Health Organization<\/a>, for a four-year term. She was nominated by the Canadian Institutes of Health Research (CIHR). This appointment recognizes her expertise in the field and furthers INRS\u2019s global impact in the fight against cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"

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