{"id":45401,"date":"2011-11-02T10:32:36","date_gmt":"2011-11-02T14:32:36","guid":{"rendered":"https:\/\/dev.inrs.ca\/?p=45401"},"modified":"2021-02-05T10:33:11","modified_gmt":"2021-02-05T15:33:11","slug":"researchers-discover-why-measles-spreads-so-quickly","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/researchers-discover-why-measles-spreads-so-quickly\/","title":{"rendered":"Researchers discover why measles spreads so quickly"},"content":{"rendered":"\n<p style=\"font-size:clamp(14px, 0.875rem + ((1vw - 3.2px) * 0.602), 19px);px\"><strong>Measles virus is perhaps the most contagious virus in the world, affecting 10 million children worldwide each year and accounting for 120,000 deaths. An <a href=\"http:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature10639.html\" target=\"_blank\" rel=\"noreferrer noopener\">article <\/a>published in the November 2, 2011 issue of <a href=\"http:\/\/www.nature.com\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Nature<\/em> <\/a>explains why this virus spreads so rapidly. The discovery by <a href=\"http:\/\/mayoresearch.mayo.edu\/staff\/cattaneo_r.cfm\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">Roberto Cattaneo<\/a>, Ph.D., at Mayo Clinic in Rochester, MN, in collaboration with Veronika von Messling, DVM, at the Centre INRS\u2013Institut Armand-Frappier and research teams at several other universities opens up promising new avenues in cancer treatment.\u00a0<\/strong><\/p>\n\n\n\n<p>Measles virus spreads from host to host primarily by respiratory secretions. This mode of transmission explains why the virus spreads so quickly and how it resists worldwide vaccination programs to eradicate it.<\/p>\n\n\n\n<p>The study in <em>Nature<\/em> shows for the first time how the measles virus \u201cexits\u201d its host via nectin-4, which is found in the trachea. While viruses generally use cellular receptors to trigger and spread infection in the body, measles virus uses one host protein to enter the host and another protein expressed at a strategic site to get out.&nbsp;<\/p>\n\n\n\n<p>Nectin-4 is a biomarker for certain types of cancer, such as breast, ovarian, and lung cancers. Clinical trials are currently under way using a modified measles virus. Because measles virus actively targets nectin-4, measles-based cancer therapy may be more successful in patients whose cancers express nectin-4. Such therapy could be less toxic than chemotherapy or radiation.<\/p>\n\n\n\n<p>Research was conducted in Dr. Cattaneo\u2019s laboratory in collaboration with the <a href=\"http:\/\/www.pei.de\/EN\/home\/node-en.html?__nnn=true\" class=\"broken_link\">Paul Ehrlich Institute<\/a> in Langen, Germany, the <a href=\"http:\/\/www.uiowa.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Iowa<\/a> in Iowa City, U.S.A., <a href=\"https:\/\/dev.inrs.ca\/en\/inrs\/research-centres\/armand-frappier-sante-biotechnologie-research-centre\/\">Centre INRS\u2013Institut Armand-Frappier<\/a> in Laval, Canada, <a href=\"http:\/\/www.institutpaolicalmettes.fr\/linstitut-paoli-calmettes\/identite-et-missions\/organisation.html\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">Inserm UMR 891\/CRCM\/Institut Paoli-Calmettes\/Universit\u00e9 d\u2019Aix-Marseille<\/a> in Marseille, France, and <a href=\"http:\/\/www.duke-nus.edu.sg\/web\/\" target=\"_blank\" rel=\"noreferrer noopener\">Duke-NUS Graduate Medical School<\/a> in Singapor.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Measles virus is perhaps the most contagious virus in the world, affecting 10 million children worldwide each year and accounting for 120,000 deaths. An article published in the November 2, 2011 issue of Nature explains why this virus spreads so rapidly. The discovery by Roberto Cattaneo, Ph.D., at Mayo Clinic in Rochester, MN, in collaboration [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[688],"tags":[],"sectors":[679],"class_list":["post-45401","post","type-post","status-publish","format-standard","hentry","category-innover-a-linrs-en","sectors-sante-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.6 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Researchers discover why measles spreads so quickly | INRS<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Researchers discover why measles spreads so quickly | INRS\" \/>\n<meta property=\"og:description\" content=\"Measles virus is perhaps the most contagious virus in the world, affecting 10 million children worldwide each year and accounting for 120,000 deaths. An article published in the November 2, 2011 issue of Nature explains why this virus spreads so rapidly. The discovery by Roberto Cattaneo, Ph.D., at Mayo Clinic in Rochester, MN, in collaboration [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.inrs.ca\/en\/news\/researchers-discover-why-measles-spreads-so-quickly\/\" \/>\n<meta property=\"og:site_name\" content=\"INRS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/inrsciences\/\" \/>\n<meta property=\"article:published_time\" content=\"2011-11-02T14:32:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-05T15:33:11+00:00\" \/>\n<meta name=\"author\" content=\"H\u00e9l\u00e8ne Simard\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@inrsciences\" \/>\n<meta name=\"twitter:site\" content=\"@inrsciences\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"H\u00e9l\u00e8ne Simard\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/researchers-discover-why-measles-spreads-so-quickly\/\",\"url\":\"https:\/\/dev.inrs.ca\/en\/news\/researchers-discover-why-measles-spreads-so-quickly\/\",\"name\":\"Researchers discover why measles spreads so quickly | INRS\",\"isPartOf\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/#website\"},\"datePublished\":\"2011-11-02T14:32:36+00:00\",\"dateModified\":\"2021-02-05T15:33:11+00:00\",\"author\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/18b5b169c8da14667452c5dcdb4b5c23\"},\"breadcrumb\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/researchers-discover-why-measles-spreads-so-quickly\/#breadcrumb\"},\"inLanguage\":\"en-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dev.inrs.ca\/en\/news\/researchers-discover-why-measles-spreads-so-quickly\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/researchers-discover-why-measles-spreads-so-quickly\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"INRS\",\"item\":\"https:\/\/dev.inrs.ca\/linrs\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Newsroom\",\"item\":\"https:\/\/dev.inrs.ca\/linrs\/salle-de-nouvelles\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"News\",\"item\":\"https:\/\/dev.inrs.ca\/linrs\/salle-de-nouvelles\/actualites\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Researchers discover why measles spreads so quickly\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/#website\",\"url\":\"https:\/\/dev.inrs.ca\/en\/\",\"name\":\"INRS\",\"description\":\"Institut national de la recherche scientifique\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dev.inrs.ca\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-CA\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/18b5b169c8da14667452c5dcdb4b5c23\",\"name\":\"H\u00e9l\u00e8ne Simard\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-CA\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/2ebf2e1f7450679f2d1b681685c76524?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/2ebf2e1f7450679f2d1b681685c76524?s=96&d=mm&r=g\",\"caption\":\"H\u00e9l\u00e8ne Simard\"},\"url\":\"https:\/\/dev.inrs.ca\/en\/author\/helene-simard\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Researchers discover why measles spreads so quickly | INRS","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"Researchers discover why measles spreads so quickly | INRS","og_description":"Measles virus is perhaps the most contagious virus in the world, affecting 10 million children worldwide each year and accounting for 120,000 deaths. 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