{"id":43686,"date":"2021-01-28T09:55:21","date_gmt":"2021-01-28T14:55:21","guid":{"rendered":"https:\/\/dev.inrs.ca\/?p=43686"},"modified":"2021-01-28T09:58:56","modified_gmt":"2021-01-28T14:58:56","slug":"discovery-of-early-plasma-biomarkers-for-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/discovery-of-early-plasma-biomarkers-for-alzheimers-disease\/","title":{"rendered":"Discovery of early plasma biomarkers for Alzheimer’s disease"},"content":{"rendered":"\n

Professor Charles Ramassamy’s research team has identified two early markers in plasma that can detect Alzheimer’s disease five years before its onset.<\/strong><\/p>\n\n\n\n

\"\"
INRS research team composed of Professor Charles Ramassamy, specialist in Alzheimer\u2019s disease, PhD student Mohamed Ra\u00e2fet Ben Khedher and postdoctoral student Mohamed Haddad (from left to right).<\/figcaption><\/figure><\/div>\n\n\n\n

The results<\/a> of this recent study led by the doctoral student Mohamed Ra\u00e2fet Ben Khedher and postdoctoral student Mohamed Haddad, directed by Professor Charles Ramassamy<\/a> of the Institut national de la recherche scientifique (INRS), have been published in the prestigious scientific journal Alzheimer’s & Dementia: Translational Research & Clinical Interventions (TRCI).<\/em><\/p>\n\n\n\n

The diagnosis of Alzheimer’s disease is usually based on a series of psychometric tests assessing cognitive function, brain imaging and cerebrospinal fluid analysis. Yet, these tests have their limitations. \u201cThe lumbar puncture is invasive, while brain imaging is expensive and not 100% reliable. This complicates regular follow-up,\u201d says Professor Ramassamy. Moreover, people with the disease are often being diagnosed at a late stage of the disease. <\/p>\n\n\n\n

\u201cWe need to find more and more early markers so we can act as soon as possible. When the disease is symptomatic, there is little, if any, way back.\u201d<\/p>Charles Ramassamy, specialist on Alzheimer’s Disease<\/cite><\/blockquote>\n\n\n\n

The research team took up this challenge by discovering two markers, detectable through a blood test, enabling them to follow the progression of the disease. These markers are found in plasma extracellular vesicles, pockets that are released by all cells in the body and circulate in the bloodstream.    <\/p>\n\n\n\n

The variation of markers<\/strong><\/h2>\n\n\n\n

The team focused specifically on the “sporadic” Alzheimer’s disease, the most common type of the disease. It stems mainly from the presence of the APOE4 susceptibility gene, the E4 variant of the gene coding for apolipoprotein. Patients with this gene who developed the disease five years later had markers present that varied with the progression of the disease.<\/p>\n\n\n\n

The research was carried out by analyzing blood samples collected as part of the Canadian Study of Health and Aging (CSHA). The population studied consisted of patients with cognitive problems, but not suffering from dementia, and only some of whom developed Alzheimer’s disease. Professor Ramassamy hopes to analyze a larger population with pre- and post-disease samples. This would allow him to determine the progression of markers after the onset of symptoms. His research on the markers located in the vesicles, opens up the possibility for studying other diseases, such as vascular dementia.<\/p>\n\n\n\n


About the study<\/strong><\/h3>\n\n\n\n

The article \u201cApolipoprotein E4-driven effects on inflammatory and neurotrophic factors in peripheral extracellular vesicles from cognitively impaired not demented participants converted to Alzheimer’s disease<\/a>\u201d follows a study<\/a> published in February 2020. The research was supported by a donation from the Charron family through the Armand-Frappier Foundation<\/a>, as part of the Louise and Andr\u00e9 Charron Research Chair in Alzheimer’s Disease<\/a>, enabling the acquisition of a crucial piece of equipment, the NanoSight NS300.<\/p>\n","protected":false},"excerpt":{"rendered":"

INRS Professor Charles Ramassamy’s research team has identified two early markers in plasma that can detect Alzheimer’s disease five years before its onset.<\/p>\n","protected":false},"author":392,"featured_media":43858,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[688],"tags":[],"sectors":[678,679],"class_list":["post-43686","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innover-a-linrs-en","sectors-biotechnologie-en","sectors-sante-en"],"acf":[],"yoast_head":"\nDiscovery of early plasma biomarkers for Alzheimer's disease | INRS<\/title>\n<meta name=\"description\" content=\"INRS Professor Charles Ramassamy's research team has identified two early markers in plasma that can detect Alzheimer's disease five years before its onset.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, 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