{"id":18562,"date":"2014-12-03T12:00:00","date_gmt":"2014-12-03T12:00:00","guid":{"rendered":"https:\/\/dev.inrs.ca\/reducing-drug-allergies-without-compromising-efficacy\/"},"modified":"2020-12-09T10:30:47","modified_gmt":"2020-12-09T15:30:47","slug":"reducing-drug-allergies-without-compromising-efficacy","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/reducing-drug-allergies-without-compromising-efficacy\/","title":{"rendered":"Reducing drug allergies without compromising efficacy"},"content":{"rendered":"\n<p><strong>An enzyme that usually triggers strong allergic reactions now circulates in the veins of a group of mice without alerting the immune system. As INRS \u00c9nergie Mat\u00e9riaux T\u00e9l\u00e9communications Research Centre Professor&nbsp;<a href=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/marc-a-gauthier\/\">Marc A. Gauthier&nbsp;<\/a>explains in an&nbsp;<a href=\"http:\/\/www.nature.com\/ncomms\/2014\/141119\/ncomms6526\/full\/ncomms6526.html\" target=\"_blank\" rel=\"noreferrer noopener\">article&nbsp;<\/a>published in the journal&nbsp;<a href=\"http:\/\/www.nature.com\/ncomms\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Nature Communications<\/em><\/a>, a polymer was used to camouflage the enzyme before it was injected into the rodents. This was achieved by coating the enzyme to avoid an immune response in a manner that does not compromise&nbsp;its activity. The first&nbsp;<em>in vivo&nbsp;<\/em>demonstration has opened the door to numerous clinical applications.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2020\/12\/NEWS_Reducing-drug-allergies-without-compromising-efficacy_01.jpg\" alt=\"\" width=\"749\" height=\"451\"\/><\/figure><\/div>\n\n\n\n<p>The strategy proposed by Professor Gauthier and his Swiss co-investigators solves a very real problem. Molecules with high therapeutic potential sometimes degrade rapidly in the bloodstream or cause allergies. This is the case for an enzyme used to fight lymphoblastic leukemia, L-asparaginase, that causes allergies in nearly 20% of patients.<\/p>\n\n\n\n<p>The research team used a comb-shaped polymer (poly-OEGMA) that covers the enzyme like a fur coat. Antibodies are unable to attach to the protected enzyme: L-asparaginase combined with poly-OEGMA is 3,000 times less recognizable by antibodies than \u201cnaked\u201d L-asparaginase.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cGenerally speaking, when other cutting-edge approaches in the field are used, enzymes are efficiently protected but lose a significant amount of their activity. We are the first to show,\u00a0<em>in vivo<\/em>, that comb-shaped polymers are much better at protecting enzymes than other approaches, since they reduce enzyme activity only slightly.\u201d<\/p><cite>Marc A. Gauthier, professor<\/cite><\/blockquote>\n\n\n\n<p>For the approach to work, the molecules that the enzyme transforms must be small enough to slide between the polymer \u201chairs.\u201d Otherwise, the reaction cannot take place. In the case of L-asparaginase, the efficacy of the approach is now proven and it can be tested on other similar enzymes.<\/p>\n\n\n\n<p>Furthermore, poly-OEGMA could protect other therapeutic molecules that are rapidly degraded, by preventing them from making contact with the proteins that inactivate or break them. This other application is equally promising.<\/p>\n\n\n\n<p><strong>About this publication<\/strong><\/p>\n\n\n\n<p>The article published in&nbsp;<em><a href=\"http:\/\/www.nature.com\/ncomms\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">Nature Communications&nbsp;<\/a><\/em>is entitled \u201c<a href=\"http:\/\/www.nature.com\/ncomms\/2014\/141119\/ncomms6526\/full\/ncomms6526.html\" target=\"_blank\" rel=\"noreferrer noopener\">Semi-permeable coatings fabricated from comb-polymers efficiently protect proteins in vivo<\/a>.\u201d The research was conducted at the Swiss Federal Institute of Technology Zurich and University Hospital Zurich by researchers Mi Liu, P\u00e5l Johansen, Franziska Zabel, Jean-Christophe Leroux, and Marc A. Gauthier, with funding from the Chinese Scholarship Council and the Sassella Foundation.&nbsp;DOI: 10.1038\/ncomms6526 <\/p>\n","protected":false},"excerpt":{"rendered":"<p>An enzyme that usually triggers strong allergic reactions now circulates in the veins of a group of mice without alerting the immune system. As INRS \u00c9nergie Mat\u00e9riaux T\u00e9l\u00e9communications Research Centre Professor&nbsp;Marc A. Gauthier&nbsp;explains in an&nbsp;article&nbsp;published in the journal&nbsp;Nature Communications, a polymer was used to camouflage the enzyme before it was injected into the rodents. This [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":38044,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[688],"tags":[],"sectors":[679],"class_list":["post-18562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innover-a-linrs-en","sectors-sante-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.6 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reducing drug allergies without compromising efficacy | INRS<\/title>\n<meta name=\"description\" content=\"An enzyme that usually triggers strong allergic reactions now circulates in the veins of a group of mice without alerting the immune system. 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