{"id":18463,"date":"2016-07-12T12:00:00","date_gmt":"2016-07-12T12:00:00","guid":{"rendered":"https:\/\/dev.inrs.ca\/mechanisms-triggering-excess-antibody-production-during-chronic-infection\/"},"modified":"2020-11-18T14:11:06","modified_gmt":"2020-11-18T19:11:06","slug":"mechanisms-triggering-excess-antibody-production-during-chronic-infection","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/mechanisms-triggering-excess-antibody-production-during-chronic-infection\/","title":{"rendered":"Mechanisms triggering excess antibody production during chronic infection"},"content":{"rendered":"\n<p><strong>Some autoimmune diseases and persistent infections are characterized by high levels of antibodies in the blood. But what are the causes of this hypergammaglobulinemia? A team headed by INRS\u2019s Professor&nbsp;<a href=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/simona-stager\/\">Simona St\u00e4ger<\/a>&nbsp;has successfully identified the mechanisms triggering the phenomenon. <\/strong><\/p>\n\n\n\n<p>For the first time ever, she has established a link between B-cell activation by a protein\u2014type 1 interferon\u2014and unusually high antibody levels.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2020\/11\/NEWS_Mechanisms-triggering-excess-antibody-production-during-chronic-infection_01.jpg\" alt=\"\" width=\"701\" height=\"422\"\/><\/figure><\/div>\n\n\n\n<p>The team has also discovered that a parasite can directly activate B cells\u2014the cells responsible for producing unusually high antibody levels. Until now, there has been no evidence that B cells can be directly stimulated by the parasite known to cause visceral leishmaniasis, a neglected and often lethal tropical disease also characterized by high levels of antibodies.&nbsp;<\/p>\n\n\n\n<p>How do&nbsp;<em>Leishmania donovani&nbsp;<\/em>parasites set off this harmful immune reaction? Proteins known as endosomal TLRs (toll-like receptors) recognize the parasites as pathogens, triggering proinflammatory responses.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cIn the case at hand, TLRs induce the secretion of interleukin-10 proteins that reduce immune responses and type 1 interferons that increase B-cell antibody production. The fact that type 1 interferons contribute to hypergammaglobulinemia induction was completely unknown.\u201d <\/p><cite>Professor St\u00e4ger<\/cite><\/blockquote>\n\n\n\n<p>Of particular interest is the fact that activation pathways may play a role in other diseases characterized by rising antibody levels that exacerbate conditions. This is a major lead as this poorly understood phenomenon causes immune reactions and other immune pathologies.<\/p>\n\n\n\n<p class=\"has-regular-font-size\">This research was headed by Professor Simona St\u00e4ger and her collaborators. Research was primarily conducted by Sasha Silva-Barrios, a doctoral student and the first author, with the assistance of M\u00e9lina Smans, a master\u2019s student at Centre INRS\u2013Institut Armand-Frappier, and Claudia U. Duerr, a postdoctoral fellow at McGill University. The results were published in Cell Reports (<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124716306118\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">doi:10.1016\/j.celrep.2016.05.028<\/a>) under the title \u201cInnate Immune B Cell Activation by&nbsp;<em>Leishmania donovani<\/em>&nbsp;Exacerbates Disease and Mediates Hypergammaglobulinemia.\u201d The Canadian Institutes of Health Research, the Centre for Host\u2013Parasite Interactions\u2019 New Initiatives Fund, and CRSNG funded the research.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Some autoimmune diseases and persistent infections are characterized by high levels of antibodies in the blood. But what are the causes of this hypergammaglobulinemia? A team headed by INRS\u2019s Professor&nbsp;Simona St\u00e4ger&nbsp;has successfully identified the mechanisms triggering the phenomenon. For the first time ever, she has established a link between B-cell activation by a protein\u2014type 1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[688],"tags":[],"sectors":[679],"class_list":["post-18463","post","type-post","status-publish","format-standard","hentry","category-innover-a-linrs-en","sectors-sante-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.6 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Mechanisms triggering excess antibody production during chronic infection | INRS<\/title>\n<meta name=\"description\" content=\"\u00a0\u00a0Some autoimmune diseases and persistent infections are characterized by high levels of antibodies in the blood. But what are the causes of this h\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanisms triggering excess antibody production during chronic infection | INRS\" \/>\n<meta property=\"og:description\" content=\"\u00a0\u00a0Some autoimmune diseases and persistent infections are characterized by high levels of antibodies in the blood. 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