{"id":18373,"date":"2017-04-03T12:00:00","date_gmt":"2017-04-03T12:00:00","guid":{"rendered":"https:\/\/dev.inrs.ca\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/"},"modified":"2020-11-12T22:21:57","modified_gmt":"2020-11-13T03:21:57","slug":"a-promising-strategy-to-increase-activity-in-antimicrobial-peptides","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/","title":{"rendered":"A promising strategy to increase activity in antimicrobial peptides"},"content":{"rendered":"\n<p><strong>In an\u00a0<a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0173783\" target=\"_blank\" rel=\"noreferrer noopener\">article\u00a0<\/a>published recently in\u00a0<em>PLoS ONE,<\/em>\u00a0researchers from\u00a0<a href=\"https:\/\/dev.inrs.ca\/linrs\/centres-de-recherche\/centre-armand-frappier-sante-biotechnologie\/\" class=\"broken_link\">INRS\u2013Institut Armand-Frappier Research Centre<\/a>\u00a0reported a strategy that could lead to the discovery of new cationic antimicrobial peptides (CAMPs) with greatly enhanced antimicrobial properties. The peptide modified for the study retained considerable activity against biofilms responsible for increasing the severity of various infections. The strategy thus holds promise for combatting multidrug resistant bacteria.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" src=\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2020\/11\/NEWS_A-promising-strategy-to-increase-activity-in-antimicrobial-peptides_01.jpg\" alt=\"\"\/><\/figure><\/div>\n\n\n\n<p>For the purpose of the study, the researchers selected a peptide\u2014pep1037\u2014already known for its antimicrobial potential and antibiofilm activity against&nbsp;<em>Pseudomonas aeruginosa<\/em>&nbsp;and&nbsp;<em>Burkholderia<\/em>, two pathogens responsible for serious complications in individuals with cystic fibrosis. The peptide was modified by adding a cysteine to the end to generate a dimer. The antimicrobial activity of the new molecule was 60 times greater than that of the original peptide.&nbsp;<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cOur results show that the dimer is of significant interest because it has a dual potential to inhibit both bacterial and biofilm growth. It could potentially be used for therapy in combination with clinically relevant antibiotics.\u201d <\/p><cite>Authors of the study<\/cite><\/blockquote>\n\n\n\n<p>Although there are currently no clinically approved antimicrobials that target bacterial biofilms, an estimated 80% of all bacterial infections have a biofilm component. These infections are much more difficult to eradicate because they are 10\u20131,000 times more resistant to antibiotic treatment. The formation of biofilms is associated with severe antibiotic resistance in the lungs of patients with cystic fibrosis, among others.&nbsp;<\/p>\n\n\n\n<p>To date, very few studies have reported on the effect of dimerizing cationic antimicrobial peptides by adding a cysteine, especially at the specific location modified by the researchers, i.e., at the end.<\/p>\n\n\n\n<p>The results obtained pave the way to improving this class of antibiotics, which occur naturally in many organisms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>About the study<\/strong><\/h2>\n\n\n\n<p>The study was conducted by Amal Thamri, Myriam L\u00e9tourneau, Alex Djoboulian,\u00a0<a href=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/david-chatenet\/\">David Chatenet<\/a>,\u00a0<a href=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/eric-deziel\/\">Eric D\u00e9ziel<\/a>,\u00a0<a href=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/annie-castonguay\/\">Annie Castonguay<\/a>, and\u00a0<a href=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/jonathan-perreault\/\">Jonathan Perreault<\/a>\u00a0of INRS-Institut Armand-Frappier Research Centre. The results are presented in the article \u201cPeptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity,\u201d which appeared in the March 2017 issue of\u00a0<a href=\"http:\/\/journals.plos.org\/plosone\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Plos One<\/em><\/a>. The researchers received financial support from Fonds de recherche du Qu\u00e9bec \u2014 Sant\u00e9; Natural Sciences and Engineering Research Council of Canada; and Fondation Armand-Frappier.\u00a0<a href=\"http:\/\/journals.plos.org\/plosone\/s\/journal-information\" target=\"_blank\" rel=\"noreferrer noopener\">DOI: 10.371\/journal.pone0173783<\/a><\/p>\n\n\n\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In an article published recently in PLoS ONE,\u00a0researchers from INRS\u2013Institut Armand-Frappier Research Centre reported a strategy that could lead to the discovery of new cationic antimicrobial peptides (CAMPs) with greatly enhanced antimicrobial properties. The peptide modified for the study retained considerable activity against biofilms responsible for increasing the severity of various infections. The strategy thus holds promise for combatting multidrug resistant bacteria.<\/p>\n","protected":false},"author":1,"featured_media":18374,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[688],"tags":[],"sectors":[679],"class_list":["post-18373","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innover-a-linrs-en","sectors-sante-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.6 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A promising strategy to increase activity in antimicrobial peptides | INRS<\/title>\n<meta name=\"description\" content=\"In an article published recently in PLoS ONE,\u00a0researchers from INRS\u2013Institut Armand-Frappier Research Centre reported a strategy that could lead to\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A promising strategy to increase activity in antimicrobial peptides | INRS\" \/>\n<meta property=\"og:description\" content=\"In an article published recently in PLoS ONE,\u00a0researchers from INRS\u2013Institut Armand-Frappier Research Centre reported a strategy that could lead to\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/\" \/>\n<meta property=\"og:site_name\" content=\"INRS\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/inrsciences\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-04-03T12:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-11-13T03:21:57+00:00\" \/>\n<meta name=\"author\" content=\"inrsadmin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@inrsciences\" \/>\n<meta name=\"twitter:site\" content=\"@inrsciences\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"inrsadmin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/\",\"url\":\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/\",\"name\":\"A promising strategy to increase activity in antimicrobial peptides | INRS\",\"isPartOf\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/\/2020\/08\/petpides2.jpg\",\"datePublished\":\"2017-04-03T12:00:00+00:00\",\"dateModified\":\"2020-11-13T03:21:57+00:00\",\"author\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/3ca476fa13dfaddd95ebd8f26337ed0f\"},\"description\":\"In an article published recently in PLoS ONE,\u00a0researchers from INRS\u2013Institut Armand-Frappier Research Centre reported a strategy that could lead to\",\"breadcrumb\":{\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#breadcrumb\"},\"inLanguage\":\"en-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-CA\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#primaryimage\",\"url\":\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/\/2020\/08\/petpides2.jpg\",\"contentUrl\":\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/\/2020\/08\/petpides2.jpg\",\"width\":640,\"height\":300},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"INRS\",\"item\":\"https:\/\/dev.inrs.ca\/linrs\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Newsroom\",\"item\":\"https:\/\/dev.inrs.ca\/linrs\/salle-de-nouvelles\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"News\",\"item\":\"https:\/\/dev.inrs.ca\/linrs\/salle-de-nouvelles\/actualites\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"A promising strategy to increase activity in antimicrobial peptides\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/#website\",\"url\":\"https:\/\/dev.inrs.ca\/en\/\",\"name\":\"INRS\",\"description\":\"Institut national de la recherche scientifique\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dev.inrs.ca\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-CA\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/3ca476fa13dfaddd95ebd8f26337ed0f\",\"name\":\"inrsadmin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-CA\",\"@id\":\"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/40b736160f83ebb228ddc350b78913ad?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/40b736160f83ebb228ddc350b78913ad?s=96&d=mm&r=g\",\"caption\":\"inrsadmin\"},\"url\":\"https:\/\/dev.inrs.ca\/en\/author\/inrsadmin\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"A promising strategy to increase activity in antimicrobial peptides | INRS","description":"In an article published recently in PLoS ONE,\u00a0researchers from INRS\u2013Institut Armand-Frappier Research Centre reported a strategy that could lead to","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"en_US","og_type":"article","og_title":"A promising strategy to increase activity in antimicrobial peptides | INRS","og_description":"In an article published recently in PLoS ONE,\u00a0researchers from INRS\u2013Institut Armand-Frappier Research Centre reported a strategy that could lead to","og_url":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/","og_site_name":"INRS","article_publisher":"https:\/\/www.facebook.com\/inrsciences\/","article_published_time":"2017-04-03T12:00:00+00:00","article_modified_time":"2020-11-13T03:21:57+00:00","author":"inrsadmin","twitter_card":"summary_large_image","twitter_creator":"@inrsciences","twitter_site":"@inrsciences","twitter_misc":{"Written by":"inrsadmin","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/","url":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/","name":"A promising strategy to increase activity in antimicrobial peptides | INRS","isPartOf":{"@id":"https:\/\/dev.inrs.ca\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#primaryimage"},"image":{"@id":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#primaryimage"},"thumbnailUrl":"https:\/\/dev.inrs.ca\/wp-content\/uploads\/\/2020\/08\/petpides2.jpg","datePublished":"2017-04-03T12:00:00+00:00","dateModified":"2020-11-13T03:21:57+00:00","author":{"@id":"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/3ca476fa13dfaddd95ebd8f26337ed0f"},"description":"In an article published recently in PLoS ONE,\u00a0researchers from INRS\u2013Institut Armand-Frappier Research Centre reported a strategy that could lead to","breadcrumb":{"@id":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#breadcrumb"},"inLanguage":"en-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/"]}]},{"@type":"ImageObject","inLanguage":"en-CA","@id":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#primaryimage","url":"https:\/\/dev.inrs.ca\/wp-content\/uploads\/\/2020\/08\/petpides2.jpg","contentUrl":"https:\/\/dev.inrs.ca\/wp-content\/uploads\/\/2020\/08\/petpides2.jpg","width":640,"height":300},{"@type":"BreadcrumbList","@id":"https:\/\/dev.inrs.ca\/en\/news\/a-promising-strategy-to-increase-activity-in-antimicrobial-peptides\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"INRS","item":"https:\/\/dev.inrs.ca\/linrs\/"},{"@type":"ListItem","position":2,"name":"Newsroom","item":"https:\/\/dev.inrs.ca\/linrs\/salle-de-nouvelles\/"},{"@type":"ListItem","position":3,"name":"News","item":"https:\/\/dev.inrs.ca\/linrs\/salle-de-nouvelles\/actualites\/"},{"@type":"ListItem","position":4,"name":"A promising strategy to increase activity in antimicrobial peptides"}]},{"@type":"WebSite","@id":"https:\/\/dev.inrs.ca\/en\/#website","url":"https:\/\/dev.inrs.ca\/en\/","name":"INRS","description":"Institut national de la recherche scientifique","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dev.inrs.ca\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-CA"},{"@type":"Person","@id":"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/3ca476fa13dfaddd95ebd8f26337ed0f","name":"inrsadmin","image":{"@type":"ImageObject","inLanguage":"en-CA","@id":"https:\/\/dev.inrs.ca\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/40b736160f83ebb228ddc350b78913ad?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/40b736160f83ebb228ddc350b78913ad?s=96&d=mm&r=g","caption":"inrsadmin"},"url":"https:\/\/dev.inrs.ca\/en\/author\/inrsadmin\/"}]}},"_links":{"self":[{"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/posts\/18373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/comments?post=18373"}],"version-history":[{"count":5,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/posts\/18373\/revisions"}],"predecessor-version":[{"id":33241,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/posts\/18373\/revisions\/33241"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/media\/18374"}],"wp:attachment":[{"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/media?parent=18373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/categories?post=18373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/tags?post=18373"},{"taxonomy":"sectors","embeddable":true,"href":"https:\/\/dev.inrs.ca\/en\/wp-json\/wp\/v2\/sectors?post=18373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}