{"id":18291,"date":"2017-11-29T12:00:00","date_gmt":"2017-11-29T12:00:00","guid":{"rendered":"https:\/\/dev.inrs.ca\/how-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations\/"},"modified":"2020-11-10T14:40:47","modified_gmt":"2020-11-10T19:40:47","slug":"how-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/how-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations\/","title":{"rendered":"How does chemotherapy among men affect the health of subsequent generations?"},"content":{"rendered":"\n<p><strong>How do cancer and cancer treatments affect the reproductive function of men? Can this affect the health of their direct descendants and subsequent generations? To get a clear picture, INRS researchers evaluate the current state of knowledge on this public health issue in a review article appearing in the journal\u00a0<em>Gyn\u00e9cologie Obst\u00e9trique &amp; Fertilit\u00e9<\/em>. They analyze the results of scientific studies to find evidence and better understand the mechanisms of action of chemotherapy on spermatogenesis. The initial observation is that cancer survivors have greater difficulty becoming fathers and use more assisted reproductive techniques, regardless of their age at diagnosis.\u00a0\u00a0<\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"667\" src=\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2017\/11\/NEWS_How-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations_01.jpg\" alt=\"\" class=\"wp-image-32343\" srcset=\"https:\/\/dev.inrs.ca\/wp-content\/uploads\/2017\/11\/NEWS_How-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations_01.jpg 1000w, https:\/\/dev.inrs.ca\/wp-content\/uploads\/2017\/11\/NEWS_How-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations_01-300x200.jpg 300w, https:\/\/dev.inrs.ca\/wp-content\/uploads\/2017\/11\/NEWS_How-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations_01-768x512.jpg 768w, https:\/\/dev.inrs.ca\/wp-content\/uploads\/2017\/11\/NEWS_How-does-chemotherapy-among-men-affect-the-health-of-subsequent-generations_01-600x400.jpg 600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure><\/div>\n\n\n\n<p>Despite a lower birth rate, it seems that having had cancer has no significant affects on the health of their children. However, there is no epidemiological study on the transgenerational effects of cancer treatments.\u00a0 There is also no data available on the reproductive function of the descendants of cancer survivors; hence the importance of continuing cohort studies over multiple generations.\u00a0\u00a0<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>\u201cIt\u2019s important to understand the mechanisms of action of chemotherapy on spermatogenesis to help clinicians make informed decisions on adjusting treatment, reducing side effects, and better advising patients on family planning.\u201d <\/p><cite><a href=\"https:\/\/dev.inrs.ca\/en\/research\/professors\/geraldine-delbes\/\">G\u00e9raldine Delb\u00e8s<\/a>, reproductive toxicology specialist and the author in charge of this study.\u00a0<\/cite><\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Highlights\u00a0<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Radiation and exposure to alkylating agents have more harmful effects on male fertility and offspring.\u00a0<\/li><li>Even without these agents, a combination of drugs can also induce the death of cells in the early cellular stage of spermatogenesis (spermatogonia) with a higher toxicity than either component alone.<\/li><li>Spermatogenesis can recover in some patients depending on the type of cancer and the dose and duration of treatment received, but such recovery is still clinically unpredictable.<\/li><li>Freezing sperm before treatment is recommended when possible.<\/li><li>Cancer and chemotherapy may affect the DNA of sperm, even after a remission period.<\/li><li>Men with a history of cancer can experience fertility issues and increased embryo loss.<\/li><li>There is no increase in transmission of genetic mutation to offspring following cancer treatments.<\/li><li>There is no significant increase in the frequency of post-natal mortality, birth defects and hospitalization rate among the children of male cancer survivors compared to the general population.\u00a0<\/li><li>There has been a decrease in side effects due to the development of better treatments, limiting the use of radiation.<\/li><li>Experimental data suggest that subtle effects can be observed on several generations supporting the need for continued multigenerational monitoring in humans.<\/li><\/ul>\n\n\n\n<p>Published in\u00a0<em><a href=\"http:\/\/www.sciencedirect.com\/journal\/gynecologie-obstetrique-and-fertilite\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">Gyn\u00e9cologie Obst\u00e9trique &amp; Fertilit\u00e9<\/a><\/em>, this research received a grant from the Cole Foundation and master\u2019s scholarships from the Canadian Institutes of Health Research and Fonds de recherche du Qu\u00e9bec \u2013 Sant\u00e9. The results are presented in the\u00a0<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S2468718917302271\" target=\"_blank\" rel=\"noreferrer noopener\" class=\"broken_link\">article\u00a0<\/a>\u201cTransgenerational impact of chemotherapy: Would the father exposure impact the health of future progeny?\u201d produced by researchers A. Tremblay, H. Beaud, and Dr. G\u00e9raldine Delb\u00e8s of INRS. DOI: 10.1016.jgofs.2017.09.004\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>How do cancer and cancer treatments affect the reproductive function of men? Can this affect the health of their direct descendants and subsequent generations? To get a clear picture, INRS researchers evaluate the current state of knowledge on this public health issue in a review article appearing in the journal Gyn\u00e9cologie Obst\u00e9trique &#038; Fertilit\u00e9. They analyze the results of scientific studies to find evidence and better understand the mechanisms of action of chemotherapy on spermatogenesis. The initial observation is that cancer survivors have greater difficulty becoming fathers and use more assisted reproductive techniques, regardless of their age at diagnosis.\u00a0\u00a0<\/p>\n","protected":false},"author":1,"featured_media":32343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[688],"tags":[],"sectors":[679],"class_list":["post-18291","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innover-a-linrs-en","sectors-sante-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.6 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How does chemotherapy among men affect the health of subsequent generations? | INRS<\/title>\n<meta name=\"description\" content=\"How do cancer and cancer treatments affect the reproductive function of men? 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