{"id":18236,"date":"2018-04-26T12:00:00","date_gmt":"2018-04-26T16:00:00","guid":{"rendered":"https:\/\/dev.inrs.ca\/neonicotinoids-may-alter-estrogen-production-in-humans\/"},"modified":"2020-11-02T16:17:13","modified_gmt":"2020-11-02T21:17:13","slug":"neonicotinoids-may-alter-estrogen-production-in-humans","status":"publish","type":"post","link":"https:\/\/dev.inrs.ca\/en\/news\/neonicotinoids-may-alter-estrogen-production-in-humans\/","title":{"rendered":"Neonicotinoids may alter estrogen production in humans"},"content":{"rendered":"<div class=\"single_entry_text\">\n<style type=\"text\/css\">\ndiv{\n    font-size: 14px;\n    line-height: 18px;\n}<\/style>\n<div><strong>An INRS team publishes the first-ever<em> in vitro <\/em>study demonstrating the potential effects of these pesticides on human health in the journal<em> <a href=\"https:\/\/ehp.niehs.nih.gov\/\" target=\"_blank\" rel=\"noopener noreferrer\">Environmental Health Perspectives<\/a><\/em>.<\/strong><\/div>\n<div>\u00a0<\/div>\n<div><img decoding=\"async\" alt=\"\" src=\"\/sites\/default\/files\/actualites-images\/centre_iaf\/pesticide.png\" style=\"width: 640px; height: 381px;\"\/><\/div>\n<div>\u00a0<\/div>\n<div>Neonicotinoids are currently the most widely used pesticides in the world and frequently make headlines because of their harmful effects on honeybees and other insect pollinators. Now, a study published in the prestigious journal <em>Environmental Health Perspectives<\/em>, indicates they may also have an impact on human health by disrupting our hormonal systems. This study by INRS professor <a href=\"http:\/\/www.iaf.dev.inrs.ca\/thomas-sanderson\" target=\"_blank\" rel=\"noopener noreferrer\">Thomas Sanderson<\/a> indicates that more work must be done on the potential endocrine-disrupting effects of neonicotinoids.\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>The Quebec government has recently decided to more strictly regulate the use of certain pesticides, including neonicotinoids, which are widely used by Quebec farmers to control crop pests. Neonicotinoids act on insects\u2019 nervous systems, killing them by paralysis. Very little research has been done on their effects on human health, but INRS Professor Sanderson and Ph.D. student \u00c9lyse Caron-Beaudoin have taken on the challenge.\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>Both researchers have long been interested in the mechanisms of endocrine disrupting chemicals and they wanted to determine whether neonicotinoids belong to this class of compounds. \u201cEndocrine disrupters are natural or synthetic molecules that can alter hormone function,\u201d says Caron-Beaudoin, the study\u2019s main author. \u201dThey affect the synthesis, action, or elimination of natural hormones, which can lead to a wide variety of health effects.\u201d\u00a0\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>The research duo has developed methods to test the effect of neonicotinoids on the production of estrogens, essential hormones with several biological functions. By targeting aromatase, a key enzyme in the synthesis of estrogens, they were able to test the impact of three neonicotinoids on breast cancer cells in culture after exposure to concentrations similar to those found in the environment in agricultural areas.\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>The results of the study show an increase in aromatase expression and a unique change in the pattern in which aromatase was expressed, which is similar to that observed in the development of certain breast cancers. \u201cHowever, as these results were obtained in a cellular model of breast cancer, we cannot necessarily conclude that exposure to pesticides at concentrations similar to those in the human environment would cause or promote cancer,\u201d cautions Professor Sanderson. This study is the first evidence that neonicotinoids have an effect on aromatase gene expression and may potentially alter estrogen production. Hormonal disturbance by these pesticides will need to be confirmed in future studies, but the results obtained by the INRS team indicate that it caution should be exercised in the management and use of neonicotinoid insecticides.<\/div>\n<div>\u00a0<\/div>\n<div><strong>About the paper<\/strong><\/div>\n<div>This study is published under the title \u201cEffects of neonicotinoid pesticides on promoter-specific aromatase (CYP19) expression in Hs578t breast cancer cells and the role of the VEGF pathway\u201d in the peer-reviewed journal <em>Environmental Health Perspectives<\/em> (DOI: <a href=\"https:\/\/doi.org\/10.1289\/EHP2698\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"broken_link\">10.1289\/EHP2698<\/a>). Principal investigator J. Thomas Sanderson received funding for this research from the National Sciences and Engineering Research Council of Canada, the California Breast Cancer Research Program and the Alternatives Research and Development Foundation. Authors \u00c9lyse Caron-Beaudoin, and Rachel Viau received scholarships from the Fonds de recherche du Qu\u00e9bec \u2013 <a href=\"http:\/\/www.frqnt.gouv.qc.ca\/en\/accueil\" target=\"_blank\" rel=\"noopener noreferrer\">Nature et technologies<\/a> (FRQNT) and the <a href=\"http:\/\/www.fondationafrappier.ca\/\" target=\"_blank\" rel=\"noopener noreferrer\">Fondation universitaire Armand-Frappier<\/a>.\u00a0<span style=\"color: rgb(0, 0, 0); font-family: Arial, Helvetica, sans-serif;\">\u2666<\/span><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>An INRS team publishes the first-ever in vitro study demonstrating the potential effects of these pesticides on human health in the journal Environmental Health Perspectives.<\/p>\n","protected":false},"author":1,"featured_media":18237,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[688],"tags":[],"sectors":[679],"class_list":["post-18236","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innover-a-linrs-en","sectors-sante-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.6 (Yoast SEO v24.6) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Neonicotinoids may alter estrogen production in humans | INRS<\/title>\n<meta name=\"description\" content=\"An INRS team publishes the first-ever in vitro study demonstrating the potential effects of these pesticides on human health in the journal Environmen\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta 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